CABT-B11385

antibody from Creative Diagnostics

Targeting: SIGLEC8 MGC59785, SAF2, SIGLEC-8, SIGLEC8L

No application information provided.

Antibody Data

Product number

CABT-B11385

Provider

Creative Diagnostics

Product name

Mouse anti-Human SIGLEC8 monoclonal antibody, clone 4I2

Antibody type

Monoclonal

Description

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM