347102

antibody from BioLegend

Targeting: SIGLEC8 MGC59785, SAF2, SIGLEC-8, SIGLEC8L

Antibody data

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Validation data

Product number: 347102 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#347102, RRID:AB_2239311
Product name: Purified anti-human Siglec-8
Antibody type: Monoclonal
Antigen: Recombinant Siglec-8 fused to human IgG Fc
Description: Siglec-8 is a lectin specific for 6'-sulfo-sLex and a member of the Ig-superfamily. It is expressed almost exclusively in eosinophils; however, basophils and mast cells can express it to a lower degree. Siglec-8 is a 54 kD transmembranal protein; the extracellular domain has one V-set Ig-like domain and two C2-set domains. The cytoplasmic domain has two immunoreceptor tyrosine-based inhibitor motifs (ITIM) that recruit SH2-family phosphatases after tyrosine phosphorylation. There are reports that siglec-8 inhibits the release of histamine and prostaglandin D2 mediated by the IgEFcR. This molelcule is also involved in the induction of apoptosis.
Reactivity: Human
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µg
Concentration: 0.5 mg/ml
Storage: The antibody solution should be stored undiluted at 4 °C.

SIGLEC8 protein structure - 347102 shown in red.