TRPV3

This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Description

Transient receptor potential cation channel subfamily V member 3

Tissue specificity

Tissue enhanced (intestine, skin)

Subcell location

Plasma membrane, Centrosome, Cytosol

Predicted location

Membrane

Protein family

Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

17 (3510502 - 3557812)

Ensembl ID

ENSG00000167723  (ver. 103.38)

Orthologs

Mouse Trpv3: ENSMUSG00000043029

UniProt

Q8NET8

neXtProt

NX_Q8NET8

Human splice variants
Mouse splice variants

Protein structure