SDCBP2

The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011]

Description

Syndecan binding protein 2

Tissue specificity

Tissue enhanced (esophagus, intestine, stomach)

Subcell location

Nucleoplasm, Golgi apparatus, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

20 (1309909 - 1329139)

Ensembl ID

ENSG00000125775  (ver. 103.38)

Orthologs

Mouse Sdcbp2: ENSMUSG00000027456

UniProt

Q9H190

neXtProt

NX_Q9H190

Human splice variants
Mouse splice variants

Protein structure