SNX6

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms. [provided by RefSeq, Jul 2008]

Description

Sorting nexin 6

Tissue specificity

Low tissue specificity

Subcell location

Endosomes, Lysosomes

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

14 (34561093 - 34630160)

Ensembl ID

ENSG00000129515  (ver. 103.38)

Orthologs

Mouse Snx6: ENSMUSG00000005656

UniProt

Q9UNH7

neXtProt

NX_Q9UNH7

Human splice variants
Mouse splice variants

Protein structure