CCL28

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Description

C-C motif chemokine ligand 28

Tissue specificity

Tissue enriched (salivary gland)

Predicted location

Intracellular, Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

5 (43376645 - 43412391)

Ensembl ID

ENSG00000151882  (ver. 103.38)

Orthologs

Mouse Ccl28: ENSMUSG00000074715

UniProt

Q9NRJ3

neXtProt

NX_Q9NRJ3

Human splice variants
Mouse splice variants

Protein structure