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Protein structure
PPM1F
Protein phosphatase, Mg2+/Mn2+ dependent 1FCAMKP, CaMKPase, FEM-2, KIAA0015, POPX2
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Proteintech Group |  17020-1-AP |
1 references | Polyclonal |
WB
EL
ICC
IP
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| Invitrogen Antibodies | PA5-112664 |
Polyclonal |
WB
EL
ICC
IHC
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| Abnova Corporation | PAB2155 |
3 references | Polyclonal |
WB
IHC
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| Cusabio Biotech Co., Ltd | CSB-PA018493LA01HU |
Polyclonal |
WB
EL
ICC
IHC
|
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| Atlas Antibodies | HPA030989 |
Polyclonal |
WB
ICC
IHC
|
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