MAP4K5

This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

Description

Mitogen-activated protein kinase kinase kinase kinase 5

Tissue specificity

Low tissue specificity

Subcell location

Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

14 (50418501 - 50561126)

Ensembl ID

ENSG00000012983  (ver. 103.38)

Orthologs

Mouse Map4k5: ENSMUSG00000034761

UniProt

Q9Y4K4

neXtProt

NX_Q9Y4K4

Human splice variants
Mouse splice variants

Protein structure