CENPH

Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008]

Description

Centromere protein H

Tissue specificity

Tissue enhanced (bone marrow, testis)

Subcell location

Nucleoplasm, Nucleoli rim, Mitotic chromosome

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

5 (69189574 - 69210357)

Ensembl ID

ENSG00000153044  (ver. 103.38)

Orthologs

Mouse Cenph: ENSMUSG00000045273

UniProt

Q9H3R5

neXtProt

NX_Q9H3R5

Human splice variants
Mouse splice variants

Protein structure