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TPP1
Tripeptidyl peptidase 1CLN2, LPIC, SCAR7, TPP-1
This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| antibodies-online |  ABIN393313 |
5 references | Monoclonal |
WB
EL
IHC
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| Novus Biologicals | H00001200-M01 |
1 references | Monoclonal |
WB
EL
IHC
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| Abnova Corporation | H00001200-M01 |
1 references | Monoclonal |
WB
EL
IHC
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| Proteintech Group | 12479-1-AP |
1 references | Polyclonal |
WB
EL
IHC
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| Acris Antibodies GmbH | AM31167PU-N |
Monoclonal |
WB
EL
IHC
|
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