AP1S2

Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as the small subunit of this complex and is a member of the adaptin protein family. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

Description

Adaptor related protein complex 1 subunit sigma 2

Tissue specificity

Tissue enriched (epididymis)

Subcell location

Golgi apparatus, Vesicles

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X (15825806 - 15854931)

Ensembl ID

ENSG00000182287  (ver. 103.38)

Orthologs

Mouse Ap1s2: ENSMUSG00000031367

UniProt

P56377

neXtProt

NX_P56377

Human splice variants
Mouse splice variants

Protein structure