GRPR

Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]

Description

Gastrin releasing peptide receptor

Tissue specificity

Tissue enriched (pancreas)

Subcell location

Plasma membrane

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

X (16123565 - 16153518)

Ensembl ID

ENSG00000126010  (ver. 103.38)

Orthologs

Mouse Grpr: ENSMUSG00000031364

UniProt

P30550

neXtProt

NX_P30550

Human splice variants
Mouse splice variants

Protein structure