CYB5R2

The protein encoded by this gene belongs to the flavoprotein pyridine nucleotide cytochrome reductase family of proteins. Cytochrome b-type NAD(P)H oxidoreductases are implicated in many processes including cholesterol biosynthesis, fatty acid desaturation and elongation, and respiratory burst in neutrophils and macrophages. Cytochrome b5 reductases have soluble and membrane-bound forms that are the product of alternative splicing. In animal cells, the membrane-bound form binds to the endoplasmic reticulum, where it is a member of a fatty acid desaturation complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Description

Cytochrome b5 reductase 2

Tissue specificity

Tissue enhanced (retina, testis)

Subcell location

Nucleoplasm, Golgi apparatus

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (7665100 - 7677222)

Ensembl ID

ENSG00000166394  (ver. 103.38)

Orthologs

Mouse Cyb5r2: ENSMUSG00000048065

UniProt

Q6BCY4

neXtProt

NX_Q6BCY4

Human splice variants
Mouse splice variants

Protein structure