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antibody from Invitrogen Antibodies
Targeting: CD93
C1qR(P), C1QR1, C1qRP, CDw93, dJ737E23.1, ECSM3, MXRA4
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Immunohistochemistry [1]
- Flow cytometry [1]
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- Product number
- 14-0939-82 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- CD93 (AA4.1) Monoclonal Antibody (R139), eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The monoclonal antibody R139 recognizes human CD93, also known as C1qRp. The glycoprotein CD93 binds to C1q, the subunit of the complement protein, mannose binding lectin and pulmonary surfactant protein A. CD93 is predicted to play a role in the clearance of apoptotic cells. Expression of CD93 is confined to myeloid cells with higher expression on monocytes than neutrophils, eosinophils, platelets and endothelial cells. Expression on DC's is downregulated upon maturation. Additionally, CD93 has been shown to define an early bone marrow stem cell population of hematopoietic and hepatic precursors.
- Antibody clone number
- R139
- Concentration
- 0.5 mg/mL
Submitted references Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface.
Short-Lived Cages Restrict Protein Diffusion in the Plasma Membrane.
Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6.
LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.
Critical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity.
SAP modulates B cell functions in a genetic background-dependent manner.
Homing and adhesion patterns determine the cellular composition of the bone marrow plasma cell niche.
A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice.
S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development.
Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad.
The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.
Systemic hypoxia enhances exercise-mediated bactericidal and subsequent apoptotic responses in human neutrophils.
PI3 kinase signals BCR-dependent mature B cell survival.
Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance.
CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche.
Prolactin alters the mechanisms of B cell tolerance induction.
CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma.
Khan KA, Naylor AJ, Khan A, Noy PJ, Mambretti M, Lodhia P, Athwal J, Korzystka A, Buckley CD, Willcox BE, Mohammed F, Bicknell R
Oncogene 2017 Nov 2;36(44):6097-6108
Oncogene 2017 Nov 2;36(44):6097-6108
Short-Lived Cages Restrict Protein Diffusion in the Plasma Membrane.
Goiko M, de Bruyn JR, Heit B
Scientific reports 2016 Oct 11;6:34987
Scientific reports 2016 Oct 11;6:34987
Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6.
Guye P, Ebrahimkhani MR, Kipniss N, Velazquez JJ, Schoenfeld E, Kiani S, Griffith LG, Weiss R
Nature communications 2016 Jan 6;7:10243
Nature communications 2016 Jan 6;7:10243
LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.
Cheng Y, Chikwava K, Wu C, Zhang H, Bhagat A, Pei D, Choi JK, Tong W
The Journal of clinical investigation 2016 Apr 1;126(4):1267-81
The Journal of clinical investigation 2016 Apr 1;126(4):1267-81
Critical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity.
Zhong MC, Veillette A
Molecular and cellular biology 2013 Mar;33(6):1223-32
Molecular and cellular biology 2013 Mar;33(6):1223-32
SAP modulates B cell functions in a genetic background-dependent manner.
Detre C, Yigit B, Keszei M, Castro W, Magelky EM, Terhorst C
Immunology letters 2013 Jun;153(1-2):15-21
Immunology letters 2013 Jun;153(1-2):15-21
Homing and adhesion patterns determine the cellular composition of the bone marrow plasma cell niche.
Belnoue E, Tougne C, Rochat AF, Lambert PH, Pinschewer DD, Siegrist CA
Journal of immunology (Baltimore, Md. : 1950) 2012 Feb 1;188(3):1283-91
Journal of immunology (Baltimore, Md. : 1950) 2012 Feb 1;188(3):1283-91
A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice.
Hao Y, O'Neill P, Naradikian MS, Scholz JL, Cancro MP
Blood 2011 Aug 4;118(5):1294-304
Blood 2011 Aug 4;118(5):1294-304
S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development.
Donovan EE, Pelanda R, Torres RM
European journal of immunology 2010 Mar;40(3):688-98
European journal of immunology 2010 Mar;40(3):688-98
Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad.
Frenzel A, Labi V, Chmelewskij W, Ploner C, Geley S, Fiegl H, Tzankov A, Villunger A
Blood 2010 Feb 4;115(5):995-1005
Blood 2010 Feb 4;115(5):995-1005
The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity.
Tavares RM, Turer EE, Liu CL, Advincula R, Scapini P, Rhee L, Barrera J, Lowell CA, Utz PJ, Malynn BA, Ma A
Immunity 2010 Aug 27;33(2):181-91
Immunity 2010 Aug 27;33(2):181-91
Systemic hypoxia enhances exercise-mediated bactericidal and subsequent apoptotic responses in human neutrophils.
Wang JS, Chiu YT
Journal of applied physiology (Bethesda, Md. : 1985) 2009 Oct;107(4):1213-22
Journal of applied physiology (Bethesda, Md. : 1985) 2009 Oct;107(4):1213-22
PI3 kinase signals BCR-dependent mature B cell survival.
Srinivasan L, Sasaki Y, Calado DP, Zhang B, Paik JH, DePinho RA, Kutok JL, Kearney JF, Otipoby KL, Rajewsky K
Cell 2009 Oct 30;139(3):573-86
Cell 2009 Oct 30;139(3):573-86
Developmental acquisition of the Lyn-CD22-SHP-1 inhibitory pathway promotes B cell tolerance.
Gross AJ, Lyandres JR, Panigrahi AK, Prak ET, DeFranco AL
Journal of immunology (Baltimore, Md. : 1950) 2009 May 1;182(9):5382-92
Journal of immunology (Baltimore, Md. : 1950) 2009 May 1;182(9):5382-92
CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche.
Chevrier S, Genton C, Kallies A, Karnowski A, Otten LA, Malissen B, Malissen M, Botto M, Corcoran LM, Nutt SL, Acha-Orbea H
Proceedings of the National Academy of Sciences of the United States of America 2009 Mar 10;106(10):3895-900
Proceedings of the National Academy of Sciences of the United States of America 2009 Mar 10;106(10):3895-900
Prolactin alters the mechanisms of B cell tolerance induction.
Saha S, Gonzalez J, Rosenfeld G, Keiser H, Peeva E
Arthritis and rheumatism 2009 Jun;60(6):1743-52
Arthritis and rheumatism 2009 Jun;60(6):1743-52
CD93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma.
Bohlson SS, Silva R, Fonseca MI, Tenner AJ
Journal of immunology (Baltimore, Md. : 1950) 2005 Jul 15;175(2):1239-47
Journal of immunology (Baltimore, Md. : 1950) 2005 Jul 15;175(2):1239-47
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemistry of formalin-fixed paraffin embedded human lung stained with 40 µg/mL Anti-Human CD93 Purified followed by Anti-Mouse IgG Biotin, Streptavidin Alkaline Phosphatase, and Fast Red (right). Nuclei are counterstained with hematoxylin.
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Staining of normal human peripheral blood cells with 0.25 µg of Mouse IgG2b kappa Isotype Control Purified (Product # 14-4732-82) (open histogram) or 0.25 µg of Anti-Human CD93 Purified (filled histogram). Cells in the monocyte gate were used for analysis.
