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Protein structure
DENND2B
DENN domain containing 2BHTS1, p126, ST5
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| antibodies-online |  ABIN2505955 |
Polyclonal |
WB
EL
ICC
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| Cusabio Biotech Co., Ltd | CSB-PA022758LA01HU |
Polyclonal |
WB
EL
IHC
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| Affinity Biosciences | DF3226 |
Polyclonal |
WB
EL
ICC
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| Biorbyt | orb686764 |
Polyclonal |
WB
EL
IHC
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| Abnova Corporation | PAB4829 |
3 references | Polyclonal |
WB
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