DPABH-24930

antibody from Creative Diagnostics

Targeting: CD274 B7-H, B7-H1, B7H1, PD-L1, PDCD1LG1, PDL1

No application information provided.

Antibody Data

Product number

DPABH-24930

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DPABH-24930, RRID:AB_2518707

Product name

Rabbit Anti-Human CD274 Polyclonal antibody

Antibody type

Polyclonal

Description

PD-L1 (programmed cell death ligand 1, also known as CD274 or B7-H1) is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. PD-L1 is suggested a negative regulator of T and B cell, and play important role in mediating tolerance of lymphocytes to self-antigens. It also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PD1-independent manner. PD-L1 is a 290 aa transmembrane protein with a calculated molecular weight of 33 kDa, it is predicted to be 27-30 kDa after signal peptide cleavage, as has been shown by several researches (PMID: 25609200