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antibody from BioLegend
Targeting: ICOSLG
B7-H2, B7h, B7H2, B7RP-1, B7RP1, CD275, GL50, ICOS-L, ICOSL, KIAA0653
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 309403 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#309403, RRID:AB_314769
- Product name
- PE anti-human CD275 (B7-H2, ICOSL)
- Antibody type
- Monoclonal
- Antigen
- Human B7H2-mIg fusion protein
- Description
- B7-H2, a member of the B7 family and the immunoglobulin superfamily, is a 40 kD protein also known as B7RP-1, B7h, B7-H2, GL50 and ICOS Ligand. Human B7-H2 is expressed by activated monocytes/macrophages and dendritic cells. B7-H2 binds to a CD28-like receptor, inducible costimulator molecule (ICOS, AILIM, CRP-1), which is expressed by activated T cells. The interaction of ICOS with B7-H2 plays an important role in the T cell costimulation pathway.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Yellow dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Modulation of T-cell activation by malignant melanoma initiating cells.
Schatton T, Schütte U, Frank NY, Zhan Q, Hoerning A, Robles SC, Zhou J, Hodi FS, Spagnoli GC, Murphy GF, Frank MH
Cancer research 2010 Jan 15;70(2):697-708
Cancer research 2010 Jan 15;70(2):697-708
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Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- Human monocyte-derived dendritic cells stained with 2D3 PE
- Conjugate
- Yellow dye
