GALNT8

This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. [provided by RefSeq, Jul 2008]

Description

Polypeptide N-acetylgalactosaminyltransferase 8

Tissue specificity

Group enriched (intestine, testis)

Subcell location

Golgi apparatus, Vesicles

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

12 (4720400 - 4851927)

Ensembl ID

ENSG00000130035  (ver. 103.38)

Orthologs

-

UniProt

Q9NY28

neXtProt

NX_Q9NY28

Human splice variants

Protein structure