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LDLR
Low density lipoprotein receptorLDLCQ2
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Top validated antibodies |
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| Novus Biologicals |  NBP1-78159 |
20 references | Monoclonal |
WB
EL
ICC
IP
IHC
FC
IEM
RA
PLA
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| Proteintech Group | 10785-1-AP |
54 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| Invitrogen Antibodies | 10785-1-AP |
Polyclonal |
WB
ICC
IP
IHC
FC
OA
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| R&D Systems | AF2148 |
19 references | Polyclonal |
WB
ICC
IHC
BN
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| GeneTex | GTX16897 |
Monoclonal |
WB
EL
ICC
IP
IHC
FC
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