NECTIN2

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Description

Nectin cell adhesion molecule 2

Tissue specificity

Low tissue specificity

Subcell location

Nucleoli fibrillar center, Cell Junctions

Predicted location

Intracellular, Membrane

Protein family

CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (44846175 - 44889223)

Ensembl ID

ENSG00000130202  (ver. 103.38)

Orthologs

Mouse Nectin2: ENSMUSG00000062300

UniProt

Q92692

neXtProt

NX_Q92692

Human splice variants
Mouse splice variants

Protein structure