CSN2

This gene is a member of the beta casein family. There are two types of casein protein, beta (encoded by this gene) and kappa, both of which are secreted in human milk. Beta casein is the principal protein in human milk and the primary source of essential amino acids for a suckling infant. Beta and kappa casein proteins acting together form spherical micelles which bind within them important dietary minerals, such as calcium and phosphorous. In addition, the C-terminal 14 aa of the protein has antimicrobial activity, especially in preterm milk, displaying antibacterial activity against S. aureus and Y. enterocolitica. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2020]

Description

Casein beta

Tissue specificity

Tissue enriched (breast)

Predicted location

Secreted in female reproductive system

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

4 (69955256 - 69961007)

Ensembl ID

ENSG00000135222  (ver. 103.38)

Orthologs

Mouse Csn2: ENSMUSG00000063157

UniProt

P05814

neXtProt

NX_P05814

Human splice variants
Mouse splice variants

Protein structure