DNAJA3

This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic proteins including ErbB2 and the p53 tumor suppressor protein. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

Description

DnaJ heat shock protein family (Hsp40) member A3

Tissue specificity

Low tissue specificity

Subcell location

Vesicles, Mitochondria

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

16 (4425805 - 4456775)

Ensembl ID

ENSG00000103423  (ver. 103.38)

Orthologs

Mouse Dnaja3: ENSMUSG00000004069

UniProt

Q96EY1

neXtProt

NX_Q96EY1

Human splice variants
Mouse splice variants

Protein structure