Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 345005 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#345005, RRID:AB_1877236
- Product name
- PE anti-human Tim-3
- Antibody type
- Monoclonal
- Antigen
- Human Tim-3 fusion protein
- Description
- Tim-3 is a transmembrane protein also known as T cell immunoglobulin and musin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Yellow dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Th1 polarized human peripheral blood mononuclear cells stained with F38 PE (top) or mouse IgG1,k isotype control PE and CD4 (RPA-T4) FITC (bottom).
- Conjugate
- Yellow dye