Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS5921 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- SCAMP1 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 293-338 of Human SCAMP1.
- Description
- Secretory carrier membrane proteins (SCAMPs) are components of the post Golgi membranes and are invovled in endocytosis, vesicle recycling and membrane trafficking. The structural features of SCAMPs include multiple N-terminal NPF repeats and four highly conserved transmembrane regions. These NPF repeats frequently interact with EH domain proteins and aid in the budding of transport vesicles from the plasma membrane or the Golgi complex. Endocytic budding at the plasma membrane and vesicle budding at the trans-Golgi complex facilitates binding of SCAMP proteins to EH domain proteins. SCAMPs exist as distinct but related proteins that include SCAMP1, SCAMP2, and SCAMP3. Tyrosine-phosphorylation by the epidermal growth factor-receptor of SCAMP1 and SCAMP3 suggests that SCAMPs are regulated by phosphorylation. Although SCAMPs are ubiquitously expressed throughout all tissue, in neural tissue the synaptic vesicles express a particularly high concentration of SCAMP1.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of SCAMP1 pAb at 1:500 dilutionLane1:A549 cell lysateLane2:Raw264.7 cell lysateLane3:PC12 cell lysate