BS9167
antibody from Bioworld Technology, Inc
Targeting: THOC5
C22orf19, Fmip, fSAP79, KIAA0983, PK1.3
Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS9167 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- FMIP (E602) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 570-624 of Human FMIP.
- Description
- Although the macrophage colony stimulating factor (M-CSF) and its receptor, c-Fms, are involved in the survival and proliferation of hematopoietic cells, little is known about the signalling events leading to differentiation into mature blood cells. A 78 kDa Fms-interacting protein, FMIP, transiently binds to M-CSFactivated Fms-molecules. This binding results in a rapid phosphorylation of FMIP within its Fms-binding domain, thereby dissociating Fms and FMIP. Endogenous levels of FMIP may form a threshold that decide whether bipotential progenitor cells differentiate into macrophages or granulocytes. Myeloid progenitor cells express low levels of endogenous FMIP and, upon M-CSF specific signalling, are differentiated into macrophages. Overexpression of FMIP may saturate Fms, which results in predominant cytoplasmic expression of FMIP and favors granulocyte differentiation.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
- Submitted by
- Bioworld Technology, Inc (provider)
- Main image
- Experimental details
- Western blot (WB) analysis of FMIP (E602) pAb at 1:500 dilutionLane1:Hela whole cell lysateLane2:NIH-3T3 whole cell lysateLane3:PC12 whole cell lysate