GYPC

Glycophorin C (GYPC) is an integral membrane glycoprotein. It is a minor species carried by human erythrocytes, but plays an important role in regulating the mechanical stability of red cells. A number of glycophorin C mutations have been described. The Gerbich and Yus phenotypes are due to deletion of exon 3 and 2, respectively. The Webb and Duch antigens, also known as glycophorin D, result from single point mutations of the glycophorin C gene. The glycophorin C protein has very little homology with glycophorins A and B. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Description

Glycophorin C (Gerbich blood group)

Tissue specificity

Tissue enhanced (bone marrow)

Subcell location

Plasma membrane

Predicted location

Membrane

Protein family

Blood group antigen proteins
CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (126656133 - 126696667)

Ensembl ID

ENSG00000136732  (ver. 103.38)

Orthologs

Mouse Gypc: ENSMUSG00000090523

UniProt

P04921

neXtProt

NX_P04921

Human splice variants
Mouse splice variants

Protein structure