PIK3C2A

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq, Jul 2008]

Description

Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Vesicles, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (17077730 - 17207983)

Ensembl ID

ENSG00000011405  (ver. 103.38)

Orthologs

Mouse Pik3c2a: ENSMUSG00000030660

UniProt

O00443

neXtProt

NX_O00443

Human splice variants
Mouse splice variants

Protein structure