ERVFRD-1

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012]

Description

Endogenous retrovirus group FRD member 1, envelope

Tissue specificity

Tissue enriched (placenta)

Subcell location

Nucleoplasm, Plasma membrane, Actin filaments, Cytosol

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

6 (11102489 - 11111725)

Ensembl ID

ENSG00000244476  (ver. 103.38)

Orthologs

-

UniProt

P60508

neXtProt

NX_P60508

Human splice variants

Protein structure