PRAM1

The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]

Description

PML-RARA regulated adaptor molecule 1

Tissue specificity

Tissue enriched (bone marrow)

Subcell location

Golgi apparatus

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (8490056 - 8502640)

Ensembl ID

ENSG00000133246  (ver. 103.38)

Orthologs

Mouse Pram1: ENSMUSG00000032739

UniProt

Q96QH2

neXtProt

NX_Q96QH2

Human splice variants
Mouse splice variants

Protein structure