MANF

The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]

Description

Mesencephalic astrocyte derived neurotrophic factor

Tissue specificity

Low tissue specificity

Subcell location

Endoplasmic reticulum

Predicted location

Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

3 (51385291 - 51389397)

Ensembl ID

ENSG00000145050  (ver. 103.38)

Orthologs

Mouse Manf: ENSMUSG00000032575

UniProt

P55145

neXtProt

NX_P55145

Human splice variants
Mouse splice variants

Protein structure