ERAP2

This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5. [provided by RefSeq, Jul 2016]

Description

Endoplasmic reticulum aminopeptidase 2

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Golgi apparatus

Predicted location

Intracellular, Secreted to blood

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

5 (96875986 - 96919703)

Ensembl ID

ENSG00000164308  (ver. 103.38)

Orthologs

-

UniProt

Q6P179

neXtProt

NX_Q6P179

Human splice variants

Protein structure