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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [3]
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- Validations
- Flow cytometry [1]
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- Product number
- FAB666P - Provider product page
- Provider
- R&D Systems
- Product name
- Human DNAM-1/CD226 PE-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from ascites. Detects human DNAM-1 in direct ELISAs and Western blots.
- Reactivity
- Human
- Host
- Mouse
- Antigen sequence
Q15762- Isotype
- IgG
- Antibody clone number
- 102511
- Vial size
- 100 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references IL-12, IL-15, and IL-18 pre-activated NK cells target resistant T cell acute lymphoblastic leukemia and delay leukemia development in vivo.
Dopamine inhibits the effector functions of activated NK cells via the upregulation of the D5 receptor.
The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia.
Boieri M, Ulvmoen A, Sudworth A, Lendrem C, Collin M, Dickinson AM, Kveberg L, Inngjerdingen M
Oncoimmunology 2017;6(3):e1274478
Oncoimmunology 2017;6(3):e1274478
Dopamine inhibits the effector functions of activated NK cells via the upregulation of the D5 receptor.
Mikulak J, Bozzo L, Roberto A, Pontarini E, Tentorio P, Hudspeth K, Lugli E, Mavilio D
Journal of immunology (Baltimore, Md. : 1950) 2014 Sep 15;193(6):2792-800
Journal of immunology (Baltimore, Md. : 1950) 2014 Sep 15;193(6):2792-800
The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia.
Brunetta E, Fogli M, Varchetta S, Bozzo L, Hudspeth KL, Marcenaro E, Moretta A, Mavilio D
Blood 2009 Oct 29;114(18):3822-30
Blood 2009 Oct 29;114(18):3822-30
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Supportive validation
- Submitted by
- R&D Systems (provider)
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- Experimental details
- Detection of DNAM-1/CD226 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) gated on CD3- cells were stained with Mouse Anti-Human DNAM-1/CD226 PE-conjugated Monoclonal Antibody (Catalog # FAB666P) and Mouse Anti-Human NCAM-1/CD56 APC-conjugated Monoclonal Antibody (Catalog # FAB2408A). Quadrant markers were set based on control antibody staining (Catalog # IC002P). View our protocol for Staining Membrane-associated Proteins.
