KCNE4

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008]

Description

Potassium voltage-gated channel subfamily E regulatory subunit 4

Tissue specificity

Tissue enhanced (smooth muscle)

Subcell location

Nuclear bodies, Microtubules

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

2 (223051814 - 223198399)

Ensembl ID

ENSG00000152049  (ver. 103.38)

Orthologs

Mouse Kcne4: ENSMUSG00000047330

UniProt

Q8WWG9

neXtProt

NX_Q8WWG9

Human splice variants
Mouse splice variants

Protein structure