SOX4

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. [provided by RefSeq, Jul 2008]

Description

SRY-box transcription factor 4

Tissue specificity

Tissue enhanced (lymphoid tissue)

Subcell location

Nucleoplasm, Mitochondria

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Transcription factors

Chromosome

6 (21593751 - 21598619)

Ensembl ID

ENSG00000124766  (ver. 103.38)

Orthologs

Mouse Sox4: ENSMUSG00000076431

UniProt

Q06945

neXtProt

NX_Q06945

Human splice variants
Mouse splice variants

Protein structure