Antibody data
- Antibody Data
- Antigen structure
- References [18]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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Validation data
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- Product number
- 12434-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12434-1-AP, RRID:AB_2199965
- Product name
- STAM antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated STAM antibody (Cat. #12434-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Upregulation of the ESCRT pathway and multivesicular bodies accelerates degradation of proteins associated with neurodegeneration.
Proximity Labeling to Identify β-Arrestin1 Binding Partners Downstream of Ligand-Activated G Protein-Coupled Receptors.
β-arrestin1 is an E3 ubiquitin ligase adaptor for substrate linear polyubiquitination.
A phosphoinositide signalling pathway mediates rapid lysosomal repair.
Neuroprogenitor Cells From Patients With TBCK Encephalopathy Suggest Deregulation of Early Secretory Vesicle Transport.
A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor.
Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.
Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.
A non-GPCR-binding partner interacts with a novel surface on β-arrestin1 to mediate GPCR signaling.
Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formation.
TIM-1 Ubiquitination Mediates Dengue Virus Entry.
The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor.
Identification of STAM1 as a novel effector of ventral projection of spinal motor neurons.
β-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4.
The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR.
The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4.
Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling.
Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4.
Benyair R, Giridharan SSP, Rivero-Ríos P, Hasegawa J, Bristow E, Eskelinen EL, Shmueli MD, Fishbain-Yoskovitz V, Merbl Y, Sharkey LM, Paulson HL, Hanson PI, Patnaik S, Al-Ramahi I, Botas J, Marugan J, Weisman LS
Autophagy reports 2023;2(1)
Autophagy reports 2023;2(1)
Proximity Labeling to Identify β-Arrestin1 Binding Partners Downstream of Ligand-Activated G Protein-Coupled Receptors.
Zhuo Y, Robleto VL, Marchese A
International journal of molecular sciences 2023 Feb 7;24(4)
International journal of molecular sciences 2023 Feb 7;24(4)
β-arrestin1 is an E3 ubiquitin ligase adaptor for substrate linear polyubiquitination.
McElrath CJ, Benzow S, Zhuo Y, Marchese A
The Journal of biological chemistry 2023 Dec;299(12):105474
The Journal of biological chemistry 2023 Dec;299(12):105474
A phosphoinositide signalling pathway mediates rapid lysosomal repair.
Tan JX, Finkel T
Nature 2022 Sep;609(7928):815-821
Nature 2022 Sep;609(7928):815-821
Neuroprogenitor Cells From Patients With TBCK Encephalopathy Suggest Deregulation of Early Secretory Vesicle Transport.
Moreira DP, Suzuki AM, Silva ALTE, Varella-Branco E, Meneghetti MCZ, Kobayashi GS, Fogo M, Ferrari MFR, Cardoso RR, Lourenço NCV, Griesi-Oliveira K, Zachi EC, Bertola DR, Weinmann KS, de Lima MA, Nader HB, Sertié AL, Passos-Bueno MR
Frontiers in cellular neuroscience 2021;15:803302
Frontiers in cellular neuroscience 2021;15:803302
A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor.
Stoneham CA, Langer S, De Jesus PD, Wozniak JM, Lapek J, Deerinck T, Thor A, Pache L, Chanda SK, Gonzalez DJ, Ellisman M, Guatelli J
PLoS pathogens 2021 Nov;17(11):e1009409
PLoS pathogens 2021 Nov;17(11):e1009409
Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.
Kazan JM, Desrochers G, Martin CE, Jeong H, Kharitidi D, Apaja PM, Roldan A, St Denis N, Gingras AC, Lukacs GL, Pause A
iScience 2021 Nov 19;24(11):103274
iScience 2021 Nov 19;24(11):103274
Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.
Zellner S, Schifferer M, Behrends C
Molecular cell 2021 Mar 18;81(6):1337-1354.e8
Molecular cell 2021 Mar 18;81(6):1337-1354.e8
A non-GPCR-binding partner interacts with a novel surface on β-arrestin1 to mediate GPCR signaling.
Zhuo Y, Gurevich VV, Vishnivetskiy SA, Klug CS, Marchese A
The Journal of biological chemistry 2020 Oct 9;295(41):14111-14124
The Journal of biological chemistry 2020 Oct 9;295(41):14111-14124
Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formation.
Mercier V, Larios J, Molinard G, Goujon A, Matile S, Gruenberg J, Roux A
Nature cell biology 2020 Aug;22(8):947-959
Nature cell biology 2020 Aug;22(8):947-959
TIM-1 Ubiquitination Mediates Dengue Virus Entry.
Dejarnac O, Hafirassou ML, Chazal M, Versapuech M, Gaillard J, Perera-Lecoin M, Umana-Diaz C, Bonnet-Madin L, Carnec X, Tinevez JY, Delaugerre C, Schwartz O, Roingeard P, Jouvenet N, Berlioz-Torrent C, Meertens L, Amara A
Cell reports 2018 May 8;23(6):1779-1793
Cell reports 2018 May 8;23(6):1779-1793
The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor.
Tian X, Irannejad R, Bowman SL, Du Y, Puthenveedu MA, von Zastrow M, Benovic JL
The Journal of biological chemistry 2016 Jul 8;291(28):14510-25
The Journal of biological chemistry 2016 Jul 8;291(28):14510-25
Identification of STAM1 as a novel effector of ventral projection of spinal motor neurons.
Nam H, Lee S
Development (Cambridge, England) 2016 Jul 1;143(13):2334-43
Development (Cambridge, England) 2016 Jul 1;143(13):2334-43
β-Arrestin1 and Signal-transducing Adaptor Molecule 1 (STAM1) Cooperate to Promote Focal Adhesion Kinase Autophosphorylation and Chemotaxis via the Chemokine Receptor CXCR4.
Alekhina O, Marchese A
The Journal of biological chemistry 2016 Dec 9;291(50):26083-26097
The Journal of biological chemistry 2016 Dec 9;291(50):26083-26097
The endosomal sorting complex required for transport pathway mediates chemokine receptor CXCR4-promoted lysosomal degradation of the mammalian target of rapamycin antagonist DEPTOR.
Verma R, Marchese A
The Journal of biological chemistry 2015 Mar 13;290(11):6810-24
The Journal of biological chemistry 2015 Mar 13;290(11):6810-24
The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4.
Holleman J, Marchese A
Molecular biology of the cell 2014 Jun 15;25(12):1892-904
Molecular biology of the cell 2014 Jun 15;25(12):1892-904
Novel roles for the E3 ubiquitin ligase atrophin-interacting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling.
Malik R, Soh UJ, Trejo J, Marchese A
The Journal of biological chemistry 2012 Mar 16;287(12):9013-27
The Journal of biological chemistry 2012 Mar 16;287(12):9013-27
Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4.
Malik R, Marchese A
Molecular biology of the cell 2010 Jul 15;21(14):2529-41
Molecular biology of the cell 2010 Jul 15;21(14):2529-41
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- PC-3 cells were subjected to SDS PAGE followed by western blot with 12434-1-AP(STAM antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using STAM antibody 12434-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line