AFF1

gene product
AF-4, AF4, MLLT2, PBM1
This gene encodes a member of the AF4/ lymphoid nuclear protein related to the Fragile X E syndrome (FRAXE) family of proteins, which have been implicated in human childhood lymphoblastic leukemia, fragile chromosome X intellectual disability, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
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258 antibodies from 28 providers.

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Novus Biologicals
4 antibodies
antibodies-online
104 antibodies
St John's Laboratory
3 antibodies
Bethyl Laboratories
2 antibodies
Boster Biological Technology
2 antibodies
Bioworld Technology, Inc
1 antibody
LifeSpan BioSciences, Inc.
46 antibodies
Biorbyt
10 antibodies
GeneTex
3 antibodies
OriGene
3 antibodies
Invitrogen Antibodies
3 antibodies
NovoPro Bioscience Inc.
1 antibody
Aviva Systems Biology
3 antibodies
Acris Antibodies GmbH
1 antibody
Proteintech Group
1 antibody
Abgent
2 antibodies
Atlas Antibodies
1 antibody
Abbexa
7 antibodies
ProSci
2 antibodies
Abiocode, Inc.
1 antibody
MyBioSource
6 antibodies
RayBiotech, Inc.
2 antibodies
Sigma-Aldrich
3 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
United States Biological
29 antibodies
Creative Diagnostics
1 antibody
Leading Biology
1 antibody