RASD1

This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Description

Ras related dexamethasone induced 1

Tissue specificity

Tissue enhanced (pituitary gland)

Subcell location

Nucleoplasm, Plasma membrane

Predicted location

Intracellular

Protein family

Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

17 (17494437 - 17496395)

Ensembl ID

ENSG00000108551  (ver. 103.38)

Orthologs

Mouse Rasd1: ENSMUSG00000049892

UniProt

Q9Y272

neXtProt

NX_Q9Y272

Human splice variants
Mouse splice variants

Protein structure