ACMSD

The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS. [supplied by OMIM, Oct 2004]

Description

Aminocarboxymuconate semialdehyde decarboxylase

Tissue specificity

Group enriched (kidney, liver)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

2 (134838616 - 134902034)

Ensembl ID

ENSG00000153086  (ver. 103.38)

Orthologs

Mouse Acmsd: ENSMUSG00000026348

UniProt

Q8TDX5

neXtProt

NX_Q8TDX5

Human splice variants
Mouse splice variants

Protein structure