Tissue expression
Cell line expression
Protein structure
DMP1
Dentin matrix acidic phosphoprotein 1Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
Novus Biologicals | NBP1-45525 | 6 references | Polyclonal |
WB
ICC |
|
Wuhan Fine Biotech Co., Ltd. | FNab10499 | Polyclonal |
WB
EL
ICC
IHC |
||
Biorbyt | orb1100557 | Polyclonal |
WB
EL
ICC
IHC |
||
Invitrogen Antibodies | PA5-103323 | 1 references | Polyclonal |
WB
OA |
|
antibodies-online | ABIN4305448 | Polyclonal |
WB
ICC
IHC
|
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider