CNTFR

This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]

Description

Ciliary neurotrophic factor receptor

Tissue specificity

Tissue enhanced (brain, skeletal muscle)

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (34551432 - 34590140)

Ensembl ID

ENSG00000122756  (ver. 103.38)

Orthologs

Mouse Cntfr: ENSMUSG00000028444

UniProt

P26992

neXtProt

NX_P26992

Human splice variants
Mouse splice variants

Protein structure