RAPGEF5

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]). [supplied by OMIM, Mar 2008]

Description

Rap guanine nucleotide exchange factor 5

Tissue specificity

Group enriched (brain, parathyroid gland)

Subcell location

Nucleoplasm, Nuclear bodies

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Chromosome

7 (22118236 - 22357154)

Ensembl ID

ENSG00000136237  (ver. 103.38)

Orthologs

Mouse Rapgef5: ENSMUSG00000041992

UniProt

Q92565

neXtProt

NX_Q92565

Human splice variants
Mouse splice variants

Protein structure