FCRL3

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Description

Fc receptor like 3

Tissue specificity

Tissue enriched (lymphoid tissue)

Predicted location

Intracellular, Membrane

Protein family

CD markers
Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

1 (157674321 - 157700769)

Ensembl ID

ENSG00000160856  (ver. 103.38)

Orthologs

-

UniProt

Q96P31

neXtProt

NX_Q96P31

Human splice variants

Protein structure