HERC6

HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]). [supplied by OMIM, Mar 2008]

Description

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (88378739 - 88443097)

Ensembl ID

ENSG00000138642  (ver. 103.38)

Orthologs

Mouse Herc6: ENSMUSG00000029798

UniProt

Q8IVU3

neXtProt

NX_Q8IVU3

Human splice variants
Mouse splice variants

Protein structure