RCN1

Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane. [provided by RefSeq, Jan 2009]

Description

Reticulocalbin 1

Tissue specificity

Tissue enriched (epididymis)

Subcell location

Endoplasmic reticulum

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (32091074 - 32105722)

Ensembl ID

ENSG00000049449  (ver. 103.38)

Orthologs

Mouse Rcn1: ENSMUSG00000005973

UniProt

Q15293

neXtProt

NX_Q15293

Human splice variants
Mouse splice variants

Protein structure