Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- BS7962 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- FANCG polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human FANCG.
- Description
- Fanconi anemia (FA) is an autosomal recessive disorder characterized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. At least 8 complementation groups (A-G) have been identified and 6 FA genes (for subtypes A, C, D2, E, F, and G) have been cloned. The FA proteins lack sequence homologies or motifs that could point to a molecular function. The cellular accumulation of FA proteins, including FANCA and FANCG, is subject to regulation by TNF-Ï« signaling. Phosphorylation of FANC (fanconi anemia complementation group) proteins is thought to be important for the function of the FA pathway. Phosphorylation of serine 7 in FANCG is functionally important in the FA pathway. FANCG is localized majorly in the nucleus and minorly in the cytoplasm, and is highly expressed in testis and thymus.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- WesternBlot (WB) analysis of FANCG polyclonal antibody