ADH7

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Description

Alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

Tissue specificity

Tissue enriched (esophagus)

Subcell location

Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4 (99412261 - 99435737)

Ensembl ID

ENSG00000196344  (ver. 103.38)

Orthologs

Mouse Adh7: ENSMUSG00000055301

UniProt

P40394

neXtProt

NX_P40394

Human splice variants
Mouse splice variants

Protein structure