Antibody data

Product number
12-3059-42 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD305 (LAIR1) Monoclonal Antibody (NKTA255), PE, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: This NKTA255 monoclonal antibody reacts with human CD305, which is also known as leukocyte-associated Ig-like receptor (LAIR) 1. CD305 is a type I transmembrane glycoprotein that possesses an extracellular Ig-like domain and two intracellular ITIMs. CD305 is expressed on nearly all immune cells, including T, NK, and B cells, as well as monocytes, dendritic cells, eosinophils, basophils, and mast cells. In humans, this molecule is also expressed on CD34+ hematopoietic progenitor cells and thymocytes. Several isoforms of CD305 exist due to alternative splicing, and their expression may differ between cell types. As an inhibitory receptor, CD305 blocks cytokine-mediated signaling, cell proliferation, and apoptosis. Studies have also identified collagens as the ligands for CD305.
Conjugate
Yellow dye
Antibody clone number
NKTA255
Concentration
5 µL/Test
LAIR1 protein structure - 12-3059-42 shown in red.