MAPK8IP1

This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]

Description

Mitogen-activated protein kinase 8 interacting protein 1

Tissue specificity

Tissue enhanced (brain, pituitary gland)

Subcell location

Plasma membrane

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins

Chromosome

11 (45885651 - 45906465)

Ensembl ID

ENSG00000121653  (ver. 103.38)

Orthologs

Mouse Mapk8ip1: ENSMUSG00000027223

UniProt

Q9UQF2

neXtProt

NX_Q9UQF2

Human splice variants
Mouse splice variants

Protein structure