DAND5

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008]

Description

DAN domain BMP antagonist family member 5

Tissue specificity

Tissue enriched (heart muscle)

Subcell location

Mitochondria

Predicted location

Secreted in other tissues

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

19 (12965159 - 12974760)

Ensembl ID

ENSG00000179284  (ver. 103.38)

Orthologs

Mouse Dand5: ENSMUSG00000053226

UniProt

Q8N907

neXtProt

NX_Q8N907

Human splice variants
Mouse splice variants

Protein structure