ITGB1BP1

The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]

Description

Integrin subunit beta 1 binding protein 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear bodies, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (9403475 - 9423528)

Ensembl ID

ENSG00000119185  (ver. 103.38)

Orthologs

Mouse Itgb1bp1: ENSMUSG00000062352

UniProt

O14713

neXtProt

NX_O14713

Human splice variants
Mouse splice variants

Protein structure